FlowTiss

Macrofluidic Flow Chamber for Cell and Tissue Experiments under Physiological Shear Stress

The chamber is not only innovative but also reusable. It enables both cultured cells and intact human tissue to be exposed to defined shear stress conditions. Unlike traditional microfluidic systems, the chamber from FlowCellInnovations provides enough space for native tissue explants and high cell numbers, enabling complex downstream analyses and significantly increasing scientific output.

Technical Features:

• Two modes of use:

a) Seeding of cells on a reusable 2×2 cm glass coverslip

b) Fixation of tissue within an integrated slit, enabling targeted exposure to flow

• Uniform shear force distribution across the entire sample

• Equipped with an openable design for easy cell seeding and harvesting

• Chemically inert Teflon body: no adsorption or interference with medium or test substances

• Post-experiment separation of flow-exposed tissue from fixed necrotic tissue for precise analysis

• Up to 10× higher cell capacity compared to standard chambers

• Reusable design, resource-efficient, and compliant with Safe and Sustainable by Design (SSbD)

principles

Applications:

• Placental research (e.g., trophoblast morphology, metabolism, omics studies)

• Drug screening and toxicity testing

• Tissue and cell studies for intestine, kidney, skin and lung in a monolayer

• Shear stress-related research in oncology, cardiology, reproductive medicine