FlowTiss BioBarrier

Dual-Channel Flow Chamber with Customized Membrane for Barrier and Co-Culture Models

This advanced flow chamber is a macrofluidic evolution of conventional microfluidic chips, designed to enable barrier modeling at a larger scale while supporting complex downstream analyses. It features a dual-channel system separated by a porous membrane, ideal for simulating physiological barriers such as maternal-fetal interfaces, kidney filtration units or intestinal uptake of nutrients, blood-tumor surface.

Technical Features:

• Top and bottom flow channels separated by a semipermeable membrane/hydrogel

• Larger cell culture surface area compared to standard chips, ideal for molecular analysis (omics approaches)

• Equipped with an openable design for easy cell seeding and harvesting

• Suitable for co-culture of different cell types (e.g., endothelial + epithelial)

• Designed to model dynamic physiological barriers

• Modular and adaptable to various organ models

• Made from inert Teflon for compatibility and reusability

Applications:

• BioBarrier simulations (placenta, kidney, lung, intestine, skin)

• Transport and permeability studies

• Cell–cell interaction experiments (e.g., immune–epithelial)

• Toxicology and pharmacokinetics research focusing on membrane transport

• Dual-compartment analysis for toxicity and interaction studies, enabling simultaneous assessment of cross-membrane effects and cell–cell responses